PARTE UTILIZADA= Used part: Corteza.

ACCIÓN FARMACOLÓGICA= Pharmacological action: Astringente

COMPOSICIÓN QUÍMICA= Chemical composition: 7-Hydroxy-1-oxo-14-norcalamenene, 7,14-dihydroxycalamenene, and sitosteryl-beta-D-glucopyranoside were obtained from T. catigua (Meliaceae).

ZONA GEOGRÁFICA= Geografical zone: Brasil, Paraguay y NE de Argentina.

ÚLTIMOS AVANCES EN LA QUÍMICA Y ACTIVIDADES BACTERIOLÓGICAS EN LAS PLANTAS MEDICINALES= Medicinal plants, last advances on chemistry and bacteria activities on the medicinal herbs

1) Phytochem. investigation of the fruit exts. of Trichilia elegans and Trichilia catigua (Meliaceae) has led to the identification of the limonoids 11beta-acetoxyobacunone, cedrelone, Me angolensate, and an epimeric mixt. of photogedunin besides known coumarins (scoparone, scopoletin, umbelliferone) and the steroids stigmasterol, beta-sitosterol, sitostenone, and campesterol.  The structures of the compds. were proposed by spectroscopic anal. and comparison with literature data.  The exts. of T. elegans showed strong insecticidal activity, and the exts. of T. catigua caused moderate larval mortality in Spodoptera frugiperda.

2) Two new phenylpropanoid-substituted epicatechins, namely, catiguanin A ( 1) and catiguanin B ( 2), were isolated from the bark of Trichilia catigua along with four known compounds, cinchonain Ia ( 3), cinchonain Ib ( 4), cinchonain Ic ( 5), and cinchonain Id ( 6).  The structures of 1 and 2 were elucidated by analysis of spectroscopic data and by comparison of their NMR data with those of previously reported cinchonains.  The isolated compounds exhibited potent antioxidant activity in the alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) radical scavenging test, with IC 50 values in the 2.3-9.4 microM range.

3) In Brazil, a herbal medicinal extract named Catuama containing a mixture of Paullinia cupana (guarana; Sapindaceae), Trichilia catigua (catuaba; Meliaceae), Ptychopetalum olacoides (muirapuama; Olacaceae) and Zingiber officinale (ginger; Zingiberaceae) is used as a body stimulant, energetic, tonic and aphrodisiac.  The present study investigated the chronic administration of 25 mL Catuama twice a day during 28 days for any toxic effect on healthy human volunteers of both sexes.  No severe adverse reactions or haematological and biochemical changes were reported.  Copyright (c) 2005 John Wiley & Sons, Ltd.

1) TOURSARKISSIAN, Martín. Plantas medicinales de Argentina : sus nombres botánicos, vulgares, usos y distribución geográfica. Buenos Aires : Hemisferio Sur, 1980, pp.86.

2) GARCEZ, W. S., et al. Sesquiterpenes from Trichilia catigua. Fitoterapia. 1997, vol.68, nº1, p.87-88.
 
3) MATOS, Andreia, et al. Chemical constituents and insecticidal activity from fruits extracts of Trichilia elegans and T. catigua (Meliaceae). Quimica Nova. 2009, vol32., nº6, p.1553-1556.
 
4) TANG, Wanxia, et al. Antioxidant phenylpropanoid-substituted epicatechins from Trichilia catigua. Journal of natural products. 2007, vol.70, nº12, p.2010-2013.
 
5) OLIVEIRA, Celso H., et al. Clinical toxicology study of an herbal medicinal extract of Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides and Zingiber officinale (Catuama) in healthy volunteers. Phytotherapy research : PTR. 2005, vol.19, nº1, p.54-57.